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In patients with thalassemia, the high levels of growth differentiation factor 15 (GDF15) and erythroferrin can also inhibit the production of hepcidin (55, 56)

Acta 16 (1), 1928

doi:10.1016/j.otsr.2023.103737 Berzolla E, Sundaram V, Strauss E

Furthermore, lactate has emerged as a key player in immune regulation, with evidence pointing to its impact on immune cell function through mechanisms such as receptor signaling via GPR81 and histone lactylation, which are closely linked to its immune-modulatory effects [16]

The established treatment paradigm now favors starting with anabolic therapy (teriparatide or abaloparatide) and then switching to an antiresorptive (bisphosphonate or denosumab) to maintain gains

Suster S, Moran CA, Rice DC